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NOW Foods, SAMe, 400 mg, Tablets Dollhouses in dolls Use it to decorate aDescription Nervous System Support Stabilized SAMe, Smaller Tablet No Enteric Coating Needed Supports Joint Health A Dietary Supplement Amino Acids SAMe (S adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to alleviate transient minor aches and pains resulting from overexertion or strain.