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Using Patch-seq, a negative correlation between the hepatocyte nuclear factor 1- (HNF1A) target gene FXYD2 (an inhibitory subunit of the Na + /K + -ATPase) and Na + influx was observed, suggesting a model whereby HNF1A facilitates membrane depolarisation and insulin secretion by upregulating sodium/potassium-transporting ATPase subunit (FXYD2)
I believe this is the group most likely to switch to injectable therapy (Wegovy/Mounjaro), because injections will be seen as a stronger or even a more dependable option
That being said, over 70% of Americans are overweight or have obesity, so even if anxiety and depression reductions are driven by weight loss and dont occur in lower weight individuals, a majority of the population may still see benefits in mental health
Zepbound Dosing Schedule Month 1 (Weeks 1-4): 2.5 mg weekly Month 2 (Weeks 5-8): 5 mg weekly Month 3 (Weeks 9-12): 7.5 mg weekly Month 4 (Weeks 13-16): 10 mg weekly Month 5 (Weeks 17-20): 12.5 mg weekly Month 6+ (Week 21+): 15 mg weekly (maximum dose) Zepbound takes longer to reach maximum dose, around 20-24 weeks
Diabetes & metabolism
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