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Restarting the medication helped restore some protection, but only partially, showing that discontinuation leaves a lasting scar. GLP-1 benefits build slowly, erode quickly GLP-1 medications include the semaglutide drugs Ozempic and Wegovy and the tirzepatide drugs Mounjaro and Zepbound

Furthermore, a recent 2026 report from risk consulting firm Aon suggested that workers sustained GLP-1 use can reduce employers costs over time

In early clinical trials, people taking the maximum dose of retatrutide lost up to 24% of their body weight after 48 weeks

Another vital step is monitoring your blood sugar levels regularly