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The Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial focused on adults aged 50 years with either established or newly diagnosed type 2 diabetes and additional cardiovascular risk factors, and this trial investigated subjects with HbA1c 9.5%, receiving up to two oral glucose-lowering drugs with or without basal insulin, and a body mass index of at least 23 kg/m 2
Wing RR, Lang W, Wadden TA, et al
Br J Dermatol 172(2):400405
They had no other clear risk factors
Swelling : Mild puffiness or localized edema often occurs as the fat cells break down
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