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FlowJo v.10.1
doi:10.4103/1673-5374.320969 Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W
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For example, the nanoparticle NanoMnSor composed of a MnO 2 core and lipid and loaded PLGA with sorafenib can co-deliver sorafenib and MnO 2, where MnO 2 can reduce hypoxia by reacting with H 2 O 2 produced by overactive metabolism of tumor cells and H + in acidic TME to produce oxygen, which can not only overcome resistance to sorafenib but also promote macrophage polarization towards the immune-stimulated M1 phenotype (61)
Therefore, exploring the role of perioperative gut microbiota and elucidating the gut-brain axis will enhance our understanding of the relationship between gut microbiota and PND
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