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These studies provide human pharmacokinetic and pharmacodynamic data, including confirmation of GH selectivity in human subjects

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280 The accumulation of unfolded or misfolded proteins triggers the unfolded protein response (UPR), an adaptive signaling network coordinated by the endoplasmic reticulum sensors IRE1, PERK, and ATF6, which functions to restore proteostasis and maintain cellular homeostasis

doi: 10.1002/pon.4155 136

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