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However, Phase 3 trials did not demonstrate sufficient efficacy for regulatory approval, and development was discontinued

2.4.3.4 Invasive procedure-related thromboembolic brain ischemia Cardiac procedures, including transcatheter and surgical valvular replacement, percutaneous and surgical coronary interventions, left atrial appendage occlusion, patent foramen ovale (PFO) closure, and AF catheter ablation, are associated with an increased risk of periprocedural cerebral ischemic injury [Table 2, (197, 280, 281)]

RNA analysis mRNA was isolated from cells or tissues using an E.Z.N.A