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In the SURMOUNT-5 trial (comparing these drugs at weight-loss doses), more people discontinued semaglutide due to side effects (5.6%) than tirzepatide (2.7%)
Up to now all the prospective GPR119 agonists were plagued by low bioavailability, lack of efficacy and more importantly, cardiotoxicity which has stopped all human studies before any large scale Phase III clinical trials (239)
A doctor will give you a shot of it under your skin once a week
if youre still uncomfortable, its common to hold longer before moving up
Frontiers in nutrition
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