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Slowly tapering the GLP-1 medication after reaching the higher dose to maintain the effects
This effect is exacerbated by rapid gastric emptying and increased incretin hormone release [22]
84, 85, 86 A tumor-suppressing effect of insulin and glucagon, and especially of their combination has been found by Salter et al
Results showed that semaglutide 1.0 mg once weekly produced superior HbA1c reductions (mean decrease of 1.5% from baseline) compared to exenatide, with patients also experiencing greater weight loss (average 5.6 kg over 56 weeks)
This triple mechanism produced 24.2% mean weight reduction in Phase 2 trials, exceeding both comparators
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