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The permeability of the leak pathway can be better assessed ex vivo by measuring the flux of molecules from the luminal to the basolateral side such as EDTA, mannitol, sucrose, inulin and polyethylene glycols (PEG) or dextran molecules of variable sizes (ranging from 4 up to 20 KDa)

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When brand-name Mounjaro costs exceed one thousand dollars monthly and peptide therapy costs for compounded versions become less favorable, switching to a more affordable option becomes necessary

The mechanism is not fully understood, but it may relate to reduced caloric intake, altered glucose metabolism, or direct central nervous system effects

Its more potent at the GIP receptor