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The unlabeled metabolomics measures static pool sizes, whereas 13 C 5 , 15 N 2 -Gln isotope tracing allows direct tracking of glutamate-derived carbon and nitrogen incorporation into GSH and -Glu-di/tripeptides, distinguishing them from other potential sources, and thus provides dynamic flux information, revealing how glutamine contributes to GSH and -Glu-di/tripeptides synthesis under certain conditions

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This pattern makes sense when you understand the mechanism

were fellows of an M.D