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[13] [15] [16] [17] [18] Fructose when consumed in excess as a sweetening agent in foods and beverages is associated with surplus calories and greater risk of obesity, diabetes, and cardiovascular disorders as components of metabolic syndrome

We propose that the effects of cumulative loss of surface receptor with fast-internalizing, slow-recycling, lysosome-targeting agonists, along with increases in -arrestin-induced desensitization, become more apparent with time, eventually overriding any positive effects associated with noncanonical signaling

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Key takeaways Digestive problems are some of Zepbounds more common side effects