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Small-molecule pan-ERR agonists extend this paradigm by directly potentiating receptor activity, enabling controlled experimental induction of the exercise program in sedentary animals

The denoised images are segmented by an automated threshold using Otsus method from Gray-Level Histograms (Binarization), and the tissue segmentation is expanded by an additional 8 pixels in each direction

2025, PMC11859134

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Preservation of lean muscle mass: Helps maintain muscle while reducing fat, improving overall body composition