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Int J Clin Pharmacol Res 1983;3(3):179-184
These findingsoriginating from landmark trials such as EMPA-REG OUTCOME, LEADER, and SUSTAIN-6have led to substantial revisions in international guidelines from the European Society of Cardiology, American College of Cardiology, and American Heart Association, which now recommend the use of SGLT2i or GLP-1 RAs, often in conjunction with metformin
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If you have any history of seizures, this combination requires extreme caution and possibly avoidance entirely
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