If you are not losing weight on semaglutide, it may be due to the following factors: You are in the early titration phase and taking low doses Individual differences such as genetics, metabolism, and starting weight Underlying health conditions such as thyroid problems, PCOS, or type 2 diabetes mellitus Unhealthy eating habits Sedentary lifestyle Missed or skipped doses Do you regain weight after stopping semaglutide
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The use of compounds that stimulate Sirtuin and AMPK modulators SIRT1/SIRT6 (e.g., resveratrol, NMN) has shown potential to restore mitochondrial biogenesis and attenuate OS in insulin-resistant tissues (Wang et al., 2023), although robust clinical trials are lacking
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