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Significant weight loss may leave patients with stretched, sagging skin, especially in the abdomen Significant weight loss, which is attainable with these effective prescriptions, may lead to loose or sagging skin as the skin loses elasticity and doesnt shrink back completely

Thats not the only claim DiStefano found

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Its use alongside ACEi/ARB, SGLT2 inhibitors and mineralocorticoid antagonists will help form the pillars of treatment for delaying the progression of CKD and reducing cardiovascular mortality. Aisling McMahon, executive director of research at Kidney Research UK, said: The results of the FLOW trial indicate semaglutide could improve quality of life for patients living with diabetes and CKD because they might be able to delay or avoid needing dialysis or transplantation, but importantly, it also showed that it reduced the risk of death from any cause