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Therefore, as evidenced by our results, different types of anticoagulants may differentially stabilize and prevent spontaneous oxidation of free GSH in plasma (with suggestive evidence that EDTA better prevents spontaneous oxidation than heparin)

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Glutathione production naturally peaks during the night

So, the biochemical studies and mitochondrial assays suggested the antioxidant and mitochondrial restoring property of hesperidin and CoQ10 and due to this these agents were responsible to produce neuroprotective effects against ketamine-induced behavioral changes in mice by restoring the protective defense system