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[79] The vast majority of valproate metabolism occurs in the liver
Study 1: STEP-1 Trial (Obesity) Published in The New England Journal of Medicine , the STEP-1 trial found that adults with obesity or overweight who received weekly semaglutide injections lost an average of about 15% of their body weight over 68 weeks, compared with just 2.4% in the placebo group
Patients considering any novel or off-label therapy should engage in shared decision-making with their GP or specialist
This has been a pivotal factor in its approval for weight management in certain patient populations
19, 2018, pp
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