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Cannabis binds to CB1 and CB2 cannabinoid receptors, also influencing appetite centers and GI motility, creating potential for additive or unpredictable effects on nausea and digestion

Several studies, such as the SUSTAIN and PIONEER trials, highlight these side effects associated with the use of semaglutide

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If you are experiencing increased urination while taking a GLP-1 medication, several factors unrelated to the drug's direct mechanism may be responsible, which warrants further evaluation to identify the underlying cause