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Group 1 received a saline injection as a control

These changes in substrate levels drive the isocitrate dehydrogenase (IDH)-mediated reductive carboxylation of -KG to produce isocitrate and citrate, which are then transported out of the mitochondria to participate in the synthesis of biomolecules such as lipids and amino acids [135]

Some GPX4 immunoreactivity was associated with the dystrophic axons in PD putamen (Figure 5D, lower right), in contrast with the lack of GPX4 found in TH-positive terminals in non-PD subjects