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doi: 10.2337/dc14-1958 209 GallwitzBVaagAFalahatiAMadsbadS

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first reported a novel form of regulated cell death with distinct morphological, biochemical, and genetic properties from the aforementioned cell death types, named ferroptosis ( 3 Ferroptosis mechanisms 3.1 Iron metabolism As one of the abundant trace elements in the crust, iron plays an imperative role in life activities such as DNA synthesis, redox reactions, enzymatic processes, cellular respiration, and metabolism ( 3+ ) bind to transferrin (Tf) on the plasma membrane, the complex is transferred into the cell by binding to the specific transferrin receptor 1 (TfR1) and localized in the endosome ( 3+ and reduces it to Fe 2+ via the six-transmembrane epithelial antigen of prostate 3 (STEAP3), which is then exported to the cytoplasm via divalent metal transporter protein 1 (DMT1) or ZRT/IRT-like protein 8/14 (ZIP8/14)