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K., Wang, Y

Before reconstitution, store these vials in the freezer at -20C for maximum stability

If a vial is smaller than the intended diluent volume, the reconstitution plan is wrong before it starts

Two procedures are performed during distinct patient encounters on the same day

Normally microglia are neuroprotective, cleaning out debris that may contribute to neurodegenerative diseases or damage from ischemic stroke, but in the case of TBI they can become overactivated and exacerbate neuroinflammation (with upregulated TNFa, IL-6, C3, NK-kB, CD68, etc), and vascular changes can result in headaches, neurovascular flow changes, impaired lymphatic flow, blood-brain barrier disruption, activation of pro-inflammatory pathways, neuronal death, hyperexcitability, and disrupted synaptic connections