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Metformin has been found to produce antidepressive effects by enhancing the responsiveness of the serotoninergic neurons in the dorsal raphe [47], but the main impact of GLP-1 is exerted by AMP-activated protein kinase (AMPK), a major cellular regulator of lipid and glucose metabolism [48]

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UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators

Metformin: sex/gender differences in its uses and effects a narrative review