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Proc Natl Acad Sci U S A 114(10):27532758

Adults were randomly assigned, 1:1:1:2, to once-daily 6 mg orforglipron, 12 mg orforglipron, 36 mg orforglipron or placebo for 72 weeks

In some research contexts, higher doses have been explored, but those studies involve close medical monitoring that is a far cry from someone self-administering based on a chart they found in a Facebook group