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10.1038/s41598-024-80856-7 84 LiX.SuY.LinN.ChenY.LiZ.ZhangZ.et al (2025b)
Patients who do both tend to lose primarily fat while preserving or even gaining muscle, resulting in a much better body composition outcome even at the same total weight loss
Beyond these findings regarding Glu and GABA, cumulative evidence has indicated dysfunction of the Gln-Glu cycle and the excitatory versus inhibitory balance (E/I balance)
The best options for a meal replacement are high in protein with at least 20-30 grams per serving, low in added sugars (ideally less than 10 grams per serving), and fortified with essential vitamins and minerals to support overall nutrition
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